Stress-dependent cortisol modulation promote avoidance conditioning through inhibitory dopamine activity in the striatum

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Jack Bortone

Abstract
Chronic intermittent hypoxia (CIH)-induced noradrenergic dysregulation is associated to increased disinhibitory dopamine activity in the paraventricular nucleus of the thalamus (PVT). Secondly, chronic hypoxic stress may increases cortisol production through a disinhibitory reuptake mechanism associated with a locus coeruleus (LC-NE)-mediated rise in extracellular dopamine levels in the dorsal striatum. Consequently, chronic intermittent hypoxia (CIH) may enhances stress-dependent cortisol responses (c-Fos expression) in the striatum through dopaminergic projections from the locus coeruleus.
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Comment #2 Jack Bortone @ 2021-03-12 02:23 (296 views)

test

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