Author Topic: Vitamin D and thrombosis  (Read 212 times)

Offline smart

  • Administrator
  • Full Member
  • *****
  • Posts: 113
    • isotoperesearch.ca
Vitamin D and thrombosis
« on: October 13, 2021, 03:22:56 PM »
Good morning,  :)

Vitamin D deficiency is correlated to increased risk of hypoxia-induced thrombosis, therefore I propose to review novel reports of vitamin D as a potential antithrombotic agent in this thread.

1. Preliminary evidences suggests that endogenous VDR expression can inhibit NLRP3 activation in hypoxic and sterile conditions:

https://www.frontiersin.org/articles/10.3389/fimmu.2021.683803/
 
2. Vitamin D is also a cheap supplement widely available without a prescription. In contrast, aspirin is no longer recommended for management and prevention of thrombosis.

3. Note: It would be therefore interesting to understand how VDR expression can suppress NLRP3 activation via PAD4 and possibly BRCC3.

4. In conclusion, it appear likely that the correlation between excessive NETs formation and thrombosis might provide evidences of the requirements of PAD4 in the pathogenesis of COVID-19 immunothrombosis: https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7488868/
 
smart

References

1. Emerging Role of Vitamin D and its Associated Molecules in Pathways Related to Pathogenesis of Thrombosis : https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC6920963/

2, Role of vitamin D in treating COVID-19-associated coagulopathy: problems and perspectives : https://link.springer.com/article/10.1007/s11010-021-04093-6
« Last Edit: October 13, 2021, 04:07:26 PM by smart »
i might be wasted sweetie but tomorrow im going to be sober and you're still going to be ugly.

Offline smart

  • Administrator
  • Full Member
  • *****
  • Posts: 113
    • isotoperesearch.ca
Re: Vitamin D and thrombosis
« Reply #1 on: October 13, 2021, 04:08:49 PM »
Quote
Fuchs et al. (42) provided a surprising observation that NETs promote thrombosis.

Source: https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC6219837/
i might be wasted sweetie but tomorrow im going to be sober and you're still going to be ugly.