Author Topic: Hypoxia-induced hibernation in humans  (Read 2964 times)

Offline smart

  • Administrator
  • Full Member
  • *****
  • Posts: 109
    • isotoperesearch.ca
Hypoxia-induced hibernation in humans
« on: September 02, 2020, 10:52:14 AM »
Abstract

The cardiovascular effects associated to intermittent face covering (chronic hypoxia) during the current WHO-declared "pandemic" are poorly understood by the scientific community promoting to "wear a mask" liberally on social networks without careful analysis of the correlated risks to human health.

In summary chronic hypoxia is correlated with multiple peroxynitrite-mediated effects as nitric oxide (NO) releases may readily reacts with carbon dioxide (CO2) to form reactive/unstable oxidative (radicals) and nitrosative species.

Consistent with our experimental findings, Advani et al (2020) reviewed a series of asymptomatic COVID19 cases associated to a multisystem inflammatory syndrome in patients thereby suggesting a role for peroxynitrite-dependent vascular dysfunction in the pathology of atherosclerosis and hyperglycemia (T2DM).
« Last Edit: February 10, 2021, 12:55:09 AM by smart »
i might be wasted sweetie but tomorrow im going to be sober and you're still going to be ugly.

Offline smart

  • Administrator
  • Full Member
  • *****
  • Posts: 109
    • isotoperesearch.ca
Re: COVID19: Long-term consequences of protective face masks on human health
« Reply #1 on: September 14, 2020, 06:54:51 PM »
Research highlights:

1. Low oxygen availability may trigger microvascular damage as chronic/intermittent hypoxia (IH) in cardiovascular patients is correlated to NO-mediated cellular damage in endothelial cells. [1]

2. IH is associated to multiple peroxynitrite-dependent microvascular injury and endothelial dysfunction in the pathology of COVID disease [2] [3] [4]

Our lab recommends further evaluation of nitric oxide (NO) and oxygen (O) role in COVID19 treatment and found several highly reliable evidences on the effects of chronic hypoxia and peroxynitrite-dependent microvascular inflammation in the pathophysiology of the disease.
« Last Edit: February 10, 2021, 12:50:06 AM by smart »
i might be wasted sweetie but tomorrow im going to be sober and you're still going to be ugly.

Offline smart

  • Administrator
  • Full Member
  • *****
  • Posts: 109
    • isotoperesearch.ca
Re: COVID19: Long-term consequences of protective face masks on human health
« Reply #2 on: September 18, 2020, 05:40:54 AM »
These findings suggest hypoxic conditions and NO-mediated dysfunction may affect endothelial transcytosis of insulin and drive hypoxia-mediated microvascular injury in the pathology of MIS-C (COVID19) syndrome.

smart
« Last Edit: January 24, 2021, 08:33:23 AM by smart »
i might be wasted sweetie but tomorrow im going to be sober and you're still going to be ugly.

Offline smart

  • Administrator
  • Full Member
  • *****
  • Posts: 109
    • isotoperesearch.ca
Re: COVID19: Long-term consequences of protective face masks on human health
« Reply #3 on: September 21, 2020, 04:01:40 AM »
Keywords: "CO2-induced vascular inflammatory disorder", platelets activation, VWF, hypoxia
« Last Edit: February 10, 2021, 12:51:39 AM by smart »
i might be wasted sweetie but tomorrow im going to be sober and you're still going to be ugly.

Offline smart

  • Administrator
  • Full Member
  • *****
  • Posts: 109
    • isotoperesearch.ca
Re: COVID19: Long-term consequences of protective face masks on human health
« Reply #4 on: September 21, 2020, 12:26:20 PM »
Chronic low-oxygen in blood cells (hypoxemia) may increase autophagy/stress (ie: Hsp72 expression) in human lung samples:

Quote
previous studies have demonstrated that in mouse models of pulmonary hypertension stimulated by chronic hypoxia, as well as in human lung samples, there is histological evidence of increased autophagy.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313568/

« Last Edit: February 04, 2021, 04:26:53 PM by smart »
i might be wasted sweetie but tomorrow im going to be sober and you're still going to be ugly.

Offline smart

  • Administrator
  • Full Member
  • *****
  • Posts: 109
    • isotoperesearch.ca
Re: COVID19: Long-term consequences of protective face masks on human health
« Reply #5 on: September 22, 2020, 07:19:09 AM »
CO2-induced vascular inflammatory disorder (COVID) is a ischemic-type condition caused by endothelial transcytosis of insulin and impaired oxygen supply in blood thereby increasing NO-dependent microvascular inflammation and platelet hyperactivation in diabetic/cardiovascular patients.

smart

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191845/
« Last Edit: January 24, 2021, 08:33:58 AM by smart »
i might be wasted sweetie but tomorrow im going to be sober and you're still going to be ugly.

Offline smart

  • Administrator
  • Full Member
  • *****
  • Posts: 109
    • isotoperesearch.ca
Re: COVID19: Long-term consequences of protective face masks on human health
« Reply #6 on: September 29, 2020, 02:22:29 AM »
CO2-induced vascular inflammatory disorder (COVID) is a ischemic-type condition caused by endothelial transcytosis of insulin and chronic low-oxygen supply in blood (hypoxia) thereby increasing peroxynitrite-dependent microvascular inflammation and platelet hyperactivation in diabetic/cardiovascular patients.

smart

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191845/

Experimental evidences suggests the increased levels of VWF, nitrated fibrinogen and ferritin biomarkers are correlated to impaired HbA1c oxygen status in red blood cells (RBCs) thereby suggesting a primary role of reactive oxygen species (ROS) and antioxidant defense in the pathogenesis of COVID-related cases. Thus, healthy people should consider minimizing the rate and frequency of CO2 rebreathing (including talking) with a face cover to prevent platelet overreactivity during low and medium intensity exercise. 

smart
« Last Edit: October 19, 2020, 08:18:52 AM by smart »
i might be wasted sweetie but tomorrow im going to be sober and you're still going to be ugly.

Offline smart

  • Administrator
  • Full Member
  • *****
  • Posts: 109
    • isotoperesearch.ca
Re: COVID19: Long-term consequences of protective face masks on human health
« Reply #7 on: October 19, 2020, 07:14:04 AM »
Preliminary findings

Our independent investigation found experimental evidences on the causative role of hypoxia-induced hibernation and impaired nitric oxide (NO) signaling in the etiology of "COVID19" phenotype (previously known as "SARS-CoV-2");  SARS-CoV-2 pathophysiology is correlated to intermittent and prolonged hypoxia in several other pathologies including MIS-C (Advani, 2020), obesity, hypertension, anemia, Type-2 Diabetes Mellitus (T2DM), and atherosclerosis.

References (Last Update: 21/01/24)

1. https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.111.00160

2. Lab notes and supplemental data: https://isotoperesearch.ca/Hypoxia
« Last Edit: January 24, 2021, 08:24:43 AM by smart »
i might be wasted sweetie but tomorrow im going to be sober and you're still going to be ugly.