Re: What is safety conditioning

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Original thread is here: https://www.thenakedscientists.com/forum/index.php?topic=82121.0

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This is a test! 

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Useful links on safety conditioning:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878001/
https://www.jneurosci.org/content/35/8/3470
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130622/

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Key points:

1. "NAccSh c-Fos is activated in animals performing SigAA"

2. My experimental findings suggests chronic/intermittent mask wearing may mimic the psychomotor effects of cocaine addiction by modulating stress-dependent dopamine (D2) receptors in the ventral striatum and nucleus accumbens shell (NAccSh): https://www.pnas.org/content/113/41/11609

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3. Persistent surgical mask use alters dopamine neurotransmission dynamics in the ventral striatum and amygdala via stress-dependent modulation of the noradrenergic system, thereby promoting conditioned avoidance learning in healthy adults. In particular this problematic behavior may induces cortisol-mediated anxiogenic effects by modulating stress-dependent dopamine D2 connectivity in the ventral striatum, thereby facilitating striatal-based memory retrieval while downregulating amygdala-hippocampal activity: https://onlinelibrary.wiley.com/doi/10.1111/ejn.14942

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"The PVN sends dense projections to the nucleus tractus solitarii (nTS), a region that displays neuronal activation following hypoxia."

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425639/

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Stress dependent dopaminergic activity caused by prolonged mask use can affect control of fear-extinction and reward processing within the ventral striatum by altering phasic dopamine signaling: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3032992/