Neuroscience and psychology > Neuroimmunology

clathrin-dependent endocytosis

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smart:
Any ideas how possibly a dreadd agonist (ie: clozapine) may use clathrin-dependent viral endocytosis pathway to mimick a low/mild pathogenic cytokine storm in lung macrophages via DC-SIGN expressing cells ?  :P

Thank you in advance....  :D

smart

smart:
As a DREADD agonist like CQ may block muscarinic receptors signaling, viral gpcr-mediated endocytosis cannot occur using DC-SIGN mediated pathway:


--- Quote ---Another way around potential off-target effects of CNO/clozapine is to employ a DREADD agonist other than CNO that does not have active metabolites, but that penetrates the BBB and selectively activates DREADDs.
--- End quote ---


Paper: https://www.nature.com/articles/npp2017299

smart:
think... think...  ::)

smart:
Since CQ is a muscarinic receptor antagonist (MRA), it may potentially block clathrin-dependent endocytosis and prevent DC-SIGN expression in lung macrophage cells.

Reference: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC136567/ 

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