Hello friends,
Resveratrol (RV) is a well-known polyphenol and antioxidant having an exceptional therapeutic profile. I would like to review in this thread a few key points about the pharmaceutical value of resveratrol.
1.
Resveratrol balances excitatory and inhibitory synaptic activity in midbrain dopamine neurons and the VTA.Liu et al [1] found that RV can efficiently restore excitatory and inhibitory activity (E/I) in dopaminergic neurons. In other words, it appears that resveratrol is a potent antidepressant that can reverse cannabis-induced drug-seeking behavior. In contrast, aripirazole, a second generation antipsychotic, has minimal therapeutic effect on heavy cannabis use and cannot prevent drug-related relapses.
Hence, it seems that resveratrol could help to manage and treat chronic cannabis use without the typical side-effects associated with modern antipsychotics like aripirazole or paliperidone.
2. Resveratrol is a PDE4 inhibitor. The same author also provided evidences about cocaine-induced PDE4 activity. In specific, PDE4 activity is associated with compulsive drug-seeking behavior. Secondly, PDE4 inhibition may improve cognition and act as a antidepressant, thereby it may help to reduce drug-associated anxiety and cravings.
3. A time for research ? Obviously, more research should be done to clarify the exact effects of resveratrol on chronic cannabis use. Likewise, PDE4 inhibiting agents such as resveratrol are functional antidepressants having a distinctive therapeutic profile for managing drug-related anxiety and depression.
References
1.
https://www.nature.com/articles/npp2017962.
https://www.sciencedirect.com/science/article/pii/S07533322210094833.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3442353/
