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Medicine / Resveratrol: an update
« Last post by smart on April 07, 2022, 05:51:47 PM »
Hello friends,

Resveratrol (RV) is a well-known polyphenol and antioxidant having an exceptional therapeutic profile. I would like to review in this thread a few key points about the pharmaceutical value of resveratrol.

1. Resveratrol balances excitatory and inhibitory synaptic activity in midbrain dopamine neurons and the VTA.

Liu et al [1] found that RV can efficiently restore excitatory and inhibitory activity (E/I) in dopaminergic neurons. In other words, it appears that resveratrol is a potent antidepressant that can reverse cannabis-induced drug-seeking behavior. In contrast, aripirazole, a second generation antipsychotic, has minimal therapeutic effect on heavy cannabis use and cannot prevent drug-related relapses.

Hence, it seems that resveratrol could help to manage and treat chronic cannabis use without the typical side-effects associated with modern antipsychotics like aripirazole or paliperidone. 

2. Resveratrol is a PDE4 inhibitor.

The same author also provided evidences about cocaine-induced PDE4 activity. In specific, PDE4 activity is associated with compulsive drug-seeking behavior. Secondly, PDE4 inhibition may improve cognition and act as a antidepressant, thereby it may help to reduce drug-associated anxiety and cravings.

3. A time for research ?

Obviously, more research should be done to clarify the exact effects of resveratrol on chronic cannabis use. Likewise, PDE4 inhibiting agents such as resveratrol are functional antidepressants having a distinctive therapeutic profile for managing drug-related anxiety and depression.


News and announcements / Re: Call for papers: Issue 1, Volume 1
« Last post by smart on February 18, 2022, 08:16:30 AM »
Open opportunities at AHNJournal

We are also actively searching for new partners to help build our platform and open community. If you would like to join our management team, you may contact us directly by using this link:

News and announcements / Call for papers: Issue 1, Volume 1
« Last post by smart on February 18, 2022, 07:40:00 AM »
Hello friend,

Applied Human Neurosecurity Journal is looking for new authors interested to publish original research on applied human neurosecurity and intelligence.

For a short introduction to human neurosecurity, please review this post :

Getting Started

Step 1 : Visit this url :

Step 2 : Create your free author profile :

Step 3 : Activate your account.  8)

Step 4 : Submit your manuscript :

Technical Support

If for some reasons you would like to report a problem when submitting your data, send a mail to .

You can also reach us on Twitter as @wise_project and @ahnjournal .

Kind regards,
New Theories / Vaccine-induced molecular mimicry
« Last post by smart on January 23, 2022, 10:43:32 AM »
Evidences suggests that SARS-CoV-2 spike protein is highly reactive with thyroid peroxidase (TPO). Interestingly, it appears likely that vaccine-induced painless thyroiditis (v-PT) might affect the antigenic properties of thyroid peroxidase autoantibodies in breast tissues through a molecular mimicry mechanism, as described by Vojdani et al.

New Theories / COVID vaccination and asthma
« Last post by smart on October 30, 2021, 05:58:12 PM »

1. Asthma is correlated to increase levels of pro-inflammatory (IL-6) cytokine:

Open questions:

1. Is there a link between atrial fibrillation pathogenesis following COVID-19 vaccination in asthmatic patients ?

Keywords: atrial fibrillation, IL-6, asthma, COVID-19 vaccination





New Theories / Re: Vitamin D and thrombosis
« Last post by smart on October 13, 2021, 04:08:49 PM »
Fuchs et al. (42) provided a surprising observation that NETs promote thrombosis.

New Theories / Vitamin D and thrombosis
« Last post by smart on October 13, 2021, 03:22:56 PM »
Good morning,  :)

Vitamin D deficiency is correlated to increased risk of hypoxia-induced thrombosis, therefore I propose to review novel reports of vitamin D as a potential antithrombotic agent in this thread.

1. Preliminary evidences suggests that endogenous VDR expression can inhibit NLRP3 activation in hypoxic and sterile conditions:
2. Vitamin D is also a cheap supplement widely available without a prescription. In contrast, aspirin is no longer recommended for management and prevention of thrombosis.

3. Note: It would be therefore interesting to understand how VDR expression can suppress NLRP3 activation via PAD4 and possibly BRCC3.

4. In conclusion, it appear likely that the correlation between excessive NETs formation and thrombosis might provide evidences of the requirements of PAD4 in the pathogenesis of COVID-19 immunothrombosis:


1. Emerging Role of Vitamin D and its Associated Molecules in Pathways Related to Pathogenesis of Thrombosis :

2, Role of vitamin D in treating COVID-19-associated coagulopathy: problems and perspectives :
Medicine / Drug-induced anorexia
« Last post by smart on August 22, 2021, 05:24:44 PM »
Dear readers,

Since using aripiprazole, patient (Jack) noticed a progressive decrease in food intake... Patient weight (148lbs) seems also to have decreased as he continues exercising on regular basis. Patient is also aware that serotonin modulation by aripiprazole may induce selective 5-HT2C activity, thereby influencing food consumption. Hence, can drug-induced serotonin modulation controls appetite and eating behaviors?  ???

What do you think?



Human neurosecurity and intelligence / Human neurosecurity fundamentals
« Last post by smart on August 14, 2021, 05:11:46 AM »
Chapter 1. Introduction
To live without getting affected by diseases requires tremendous personal work in order to gain self-knowledge about medicine and mental health. Unfortunately, very few of us are motivated to develop and protect our genuine intelligence to prevent diseases. In contrast, when doing experiments to study my internal mental states, I am using an experimental method to acquire self-knowledge in a controlled way. Interestingly, as a experimenter, I consistently enjoy to have the freedom to analyze my own thoughts and behavior without being judged by a third-party agent. Thus, I don’t expect people to understand most of my own thoughts, but I hope that people can read my mind while reading this post.  :)

Chapter 2. Free neurosecurity training for all

In the last years I have learned that psychiatry is not made for everyone. People having normal behavior generally can avoid psychiatric drugs when committing themselves to have a socially acceptable behavior. I have been coerced many times to accept antipsychotics, simply because people cannot understand me properly. As I am writing these lines, I’m still struggling to find a way to convince other peoples that psychiatric treatment is useless and potentially harmful to my health. Unfortunately, changing the paradigm in health care is a slow process requiring profound changes in the public health industry. Many psychiatrists will prefer to give higher doses of antipsychotics without any scientific justification for this treatment type. This industrial mindset doesn’t specifically suits my own needs and can lead to abuses. 

Hence, free neurosecurity training is dedicated to fill the gap between the physician and the patient. First, by enhancing dialectical neurosecurity in healthy subjects, neurosecurity training can promote a pro-feminist and equal-for-all mental health approach. Likewise, by promoting free access to psychological counseling, psychiatric treatment becomes useless for people with normal behavior.

But what happens when someone cannot afford to receive free psychological counseling? Modern psychiatry is not a panacea and neither a long-term solution for people with prosocial behavior. Thus, there’s a clear and urgent need for alternative solutions in order to decrease pressure on the public health industry.

To compensate with the inefficient public health industry is thus a prime goal of applied human neurosecurity. Technically, this paradigm change may require a specific mindset in order to commit oneself in studying his own dialectical thinkings. Mind wandering, as the capacity to transcend thoughts into specific behavioral responses, can promote self-learning of human consciousness. It is this specific human response that can structure the mind in a logical way. In the next chapter, I will review Project STREET WISE, a experimental case-study on problematic smartphone use (PSU), a serious public health issue that can affect and potentially impair cognitive flexibility in a typical long-term user.

Chapter 3. Problematic smartphone use

Project STREET WISE has been for me a way to learn more about problematic smartphone use and the emerging public health disaster associated to this novel pathology. Interestingly, I’ve been collecting notes to understand the etiology of PSU in a typical female smartphone user (FSU) located in the Quebec region. (St-Jerome).

I was very interested in understanding the differences in typical smartphone usage between male and female users. I found that female users typically becomes emotionally attached to their smartphone, becoming part of their identity. In contrast, I’ve noticed that male subjects were sometimes becoming aggressive when attempting to discuss with them in the streets about their problematic smartphone usage.

Interestingly, most smartphone users tend to develop an intimate relationship with their mobile device, making me wonder how the brain may become addicted to chronic smartphone use. Based on this starting point, it became obvious that regular mobile device usage does affect the brain of the user without his full awareness or consent.

In a nutshell, I’ve been compiling experimental data about the pathogenesis of digital radicalisation, a secondary issue associated to problematic smartphone use. I’ve then noticed that many online users do share problematic smartphone use patterns connected to digital radicalisation when posting content on social networks.

In summary, Project STREET WISE helped me to develop a coherent and functional theory on mind wandering, the starting point in my research on problematic smartphone use. Although I’m not a qualified scientist, working on this research subject helped me to gain deep knowledge on ways to exploit mind wandering when interacting with others. In the next chapter, I will discuss about novel ways to harness mind wandering for improving human neurosecurity.

Chapter 4. Neuropsychology of mind wandering

In my experience the best available way to exercise and stimulate self-awareness of my consciousness is by walking alone at a steady speed during an extended period of time. I’ve become so addicted to walking that i try to convince myself of walking on a daily basis for a minimum of 30-60 minutes.
This period of the day is dedicated to release stress resulting from my repeated failures to find a productive way to earn money, or employment, I believe.

Being without employment indeed is a source of pathological stress that I must overcome every day by working towards my own specific life goals, independently of my former career as a software programmer. That is, to understand my own misfortune is a necessary step that I like to work on in order to find alternative solutions.

Hence, writing this book is actually helpful for understanding my current research in developmental neurosecurity. In other words, I’ve developed a novel research domain based on practical mind wandering, in order to obtain reliable informations about my self-defined identity as a developer, scientist, and writer.

Part of my future plans includes building a microjournal in order to promote awareness of this emerging research field. I’m also trying to become a better developer and scientist by working in these specific domains using my limited knowledge.

All these experiments helped me to understand the limits of my human intelligence. In specific, human neurosecurity is an open access research field. Most importantly, as a citizen science movement, applied human neurosecurity training aims to promote an accessible and equal-for-all scientific method to create and preserve human knowledge. In the next chapter, I will review the core technical aspects of studying human neurosecurity for prospective experimenters wishing to dive into more advanced topics.

Chapter 5. Developmental and adaptive bioneurosecurity

This chapter covers the core basics and fundamentals of applied human neurosecurity training. First, it is essential to understand the functions of mind wandering in order to dedicate oneself into the experimental science of human neurosecurity training. Thus, mind wandering can be seen as a developmental, adaptive, and human-friendly framework in order to enhance knowledge acquisition. Moreover, my current research suggest that the human brain has excellent innate capacity to learn and unlearn a massive quantity of informations.

This “meta-information” unfortunately is not accessible without conducting experiments on myself. It is by exercising this experience-type paradigm that I alone can go further into my own abstract thinkings, thereby redefining my own cognitive limits as a human. Hence, I believe this novel human learning paradigm to be challenging our common views on the psychology of mind wandering itself and machine-based intelligence.

Chapter 6. Applied human neurosecurity fundamentals

Abstract human knowledge is created dynamically from novel experiences generating long-term memories and consciousness. In contrast, a core problem with problematic smartphone use can be associated to impaired dialectical processing of novel meta informations in chronic users. This result in irregular processing of synthetic-like knowledge, influencing long-term regulation of the brain (higher-order) neuronal activity.

Likewise, social networks provides reliable evidences of the problematic smartphone use cyberpathology: First, by aggressively exploiting artificial intelligence to promote inhibitory (passive) avoidance, excessive smartphone use might impair dialectical self-processing in chronic users, thereby influencing the user decision to accept or decline a experimental vaccine regimen.

Consequently, there is urgent need to better understand how dialectical processing can be impaired with excessive mobile device use, potentially leading to machine-based abuses of human rights. In contrast, applied neurosecurity training might protect the integrity of human knowledge by enhancing semantic and contextual learning of novel experiences, thereby reversing aversive fear conditioning.

In other words, the problematic smartphone use pathology provides significant evidences that applied human neurosecurity training can be a successful therapy for improving human dialectical processing agaisnt machine-generated online disinformation and propaganda. In the next chapter, the reader can read more about the aim and scope of applied human neurosecurity research.

Chapter 7. Human neurosecurity advocacy and research

Fundamentally, applied human neurosecurity training is a feminist-friendly research domain aiming to create experential knowledge on the psychology of metacognition and human self-learning. Hence, I strongly believe public health must be redesigned to promote fair and equal access to experimental medicine and psychology, in order to prevent abuses and medical errors with the outdated mental health industry.

Moreover, the scientific method proposed through this book to build self-knowledge is controlled exclusively by the subject via dialectical self-processing of conscious experiences. Unlike in the traditional public health system, applied neurosecurity cannot be exported to someone else.

Chapter 8. Self-experimentation as a scientific method to investigate human consciousness.

The nature of dialectical self-thinking requires experimental training to acquire and consolidate new knowledge empirically. For example, when learning a new language, it can be helpful to exercise reading and writing without having full knowledge on the subject. Human neurosecurity training aims to promote a experience-driven approach to develop natural knowledge through conscious experimentation.

In contrast, human experimentation in psychiatry and medicine is typically not controlled by patients. This opens the door to psychiatric abuses and medical errors that can negatively affect long-term health. Thus, a persisting challenge of this current decade is to educate healthy citizens in becoming responsible in the management of their mental and physical health without strictly depending on a foreign party.

Although modern psychiatric treatment often can sometimes affect or damage long-term health, I believe that applied human neurosecurity training can attenuate the side-effects associated to psychiatry, by promoting positive self-affirmation of the subject social identity. Nonetheless, it appears likely that psychiatry can have positive outcomes when combined with a scientific method to create self-confidence in the patient.   

Furthermore, a psychiatrist may prescribe drugs affecting the central nervous system requiring the patient consent. By establishing a positive trust relationship between the patient and the psychiatrist, the subject can self-control the outcomes regarding the prescribed treatment.

Chapter 9. A feminist method to applied neurosecurity training

The progressive development of a feminist and experimental method to build self-knowledge is the primacy of applied neurosecurity training and does require a steady mindset for reaching this long-term objective as a human being.

General Discussion / Re: What is AHNJournal?
« Last post by smart on June 29, 2021, 07:35:24 AM »

I am currently planning to test an implementation of janeway as our main publishing platform and management backend of Applied Human Neurosecurity Journal (AHNJournal).

The site is currently in beta testing phase:

Documents can be submitted for peer-review here:

In addition, the next release will allow authors to post articles, preprints, and letters (comments).

Source code

The source code can be downloaded from Github:

Kind regards,
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