Stress-dependent cortisol modulation promote avoidance conditioning through inhibitory dopamine activity in the striatum

Abstract

Chronic intermittent hypoxia (CIH)-induced noradrenergic dysregulation is associated to increased disinhibitory dopamine activity in the paraventricular nucleus of the thalamus (PVT). Secondly, chronic hypoxic stress may increases cortisol production through a disinhibitory reuptake mechanism associated with a locus coeruleus (LC-NE)-mediated rise in extracellular dopamine levels in the dorsal striatum. Consequently, chronic intermittent hypoxia (CIH) may enhances stress-dependent cortisol responses (c-Fos expression) in the striatum through dopaminergic projections from the locus coeruleus.

Keywords

stress, dopamine, thalamus, hypoxia, ptsd, addiction

How to Cite

Bortone J., (2021) “Stress-dependent cortisol modulation promote avoidance conditioning through inhibitory dopamine activity in the striatum”, Applied Human Neurosecurity Journal 1(0).

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Jack Bortone (AHNJournal)

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Creative Commons Attribution-ShareAlike 4.0

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This article has not been peer reviewed.

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